Chemical Information

Acetaminophen - An acetanilide with analgesic and antipyretic activity. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, this agent probably acts by inhibiting prostaglandin synthesis in the central nervous system (CNS). Inhibition of prostaglandin synthesis in the CNS results in elevation of the pain threshold and lowering of the thermal set point in the hypothalamus.

Diphenhydramine Hydrochloride - The hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.